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Turnover of 131 I‐human spleen ferritin in plasma
Author(s) -
Cragg Susan J.,
Covell Ann M.,
Burch Anna,
Owen Glynn M.,
Jacobs Allan,
Worwood Mark
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.tb01226.x
Subject(s) - ferritin , spleen , human plasma , plasma clearance , chemistry , endocrinology , medicine , metabolic clearance rate , biology , biochemistry , chromatography , pharmacokinetics
S ummary . Human spleen ferritin was labelled with 131 I and injected into two normal men. The labelled ferritin left the plasma rapidly. The experimental clearance curve could be fitted with accuracy into two single exponential functions. The first component, T 1/2 = 9 min, accounted for the clearance of about 90% of the labelled ferritin. Surface counting showed uptake of 131 I by the liver but not by the spleen. Such a rapid plasma turnover is similar to that found after injection of tissue ferritins into experimental animals but contrasts with the slow turnover previously found for 131 I‐labelled human plasma ferritin. Differential clearance of isoferritins from the plasma is an important factor explaining the biochemical and immunological differences between tissue and plasma ferritins.