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T cell regeneration after allogeneic and autologous bone marrow transplantation
Author(s) -
Linch D. C.,
Knott L. J.,
Thomas R.M.,
Harper P.,
Goldstone A. H.,
Davis E. G.,
Levinski R.J.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.00411.x-i1
Subject(s) - bone marrow , medicine , immunology , transplantation , monoclonal antibody , thymocyte , t cell , human leukocyte antigen , antigen , antibody , immune system
S ummary . Venous blood T cell phenotypes were analysed with monoclonal antibodies after 11 allogeneic and 17 autologous bone marrow transplants. In seven cases studied in the early regenerative period, cells with a thymocyte phenotype were present in the blood. In the large majority of patients treated with both allografts and autografts there was an imbalance of phenotypic ‘helper’ and ‘suppressor’ T cell subsets with initially a relative and later an absolute increase of ‘suppressor’ T cells. This imbalance was still present at over 250 d in eight out nine cases. Suppressor T cells bearing HLA‐Dr antigens were abundant in one case of fatal GVHD but not in another, and were also increased following two autografts. It is concluded that T cell phenotyping is not of diagnostic value in sick patients following bone marrow transplantation when graft‐versus‐host disease is suspected.