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RECOGNITION OF MARROW ELEMENTS BY NATURAL KILLER CELLS: ARE NK CELLS INVOLVED IN HAEMOPOIETC REGULATION?
Author(s) -
O'Brien T. K.,
Kendra J. A.,
Stephens H. A. F.,
Knight R. A.,
Barrett A. J.
Publication year - 1983
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1983.00153.x-i1
Subject(s) - bone marrow , cytolysis , lymphokine activated killer cell , biology , immunology , progenitor cell , cytotoxicity , in vitro , interleukin 21 , microbiology and biotechnology , cancer research , stem cell , t cell , immune system , genetics
S ummary . NK cells from young normal mice are cytolytic in vitro for a virus‐induced tumour cell line, YAC‐1. Cytotoxicity is inhibited by the addition of unlabelled homologous YAC‐1 cells and by regenerating bone marrow cells from the spleens of lethally irradiated, bone‐marrow‐grafted mice. Quiescent marrow from syngeneic and allogeneic mice produces little or no competition. This suggests that NK cells recognize, and may regulate, marrow progenitor cells.