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DEMONSTRATION OF UROKINASE‐RELATED FIBRINOLYTIC ACTIVITY IN HUMAN PLASMA
Author(s) -
Wijngaards G.,
Kluft C.,
Groeneveld E.
Publication year - 1982
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1982.tb07300.x
Subject(s) - urokinase , human plasma , fibrinolysis , fibrinolytic agent , medicine , chemistry , tissue plasminogen activator , chromatography
Various preparations of anti‐urokinase antibodies were found to quench a part of the plasma fibrinolytic activity. This part was also inhibited by a specific, urokinase inhibitor isolated from placenta. These observations indicate that plasma contains a urokinase‐related immuno‐reactivity. This activity was found to belong to the factor XII‐independent proactivator system.