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Deficient natural killer (NK) cell activity in paroxysmal nocturnal haemoglobinuria (PNH)
Author(s) -
Yoda Yasuhiro,
Abe Tsukasa,
Mitamura Keiji,
Saito Kenji,
Kawada Kenichi,
Onozawa Yasusuke,
Adachi Yamao,
Nomura Takeo
Publication year - 1982
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1982.tb03931.x
Subject(s) - peripheral blood mononuclear cell , immunology , natural killer cell , abnormality , lymphocyte , cell , interferon , in vitro , medicine , biology , cytotoxic t cell , genetics , psychiatry
S ummary . Natural killer (NK) cell activity was studied in nine patients with paroxysmal nocturnal haemoglobinuria (PNH) and 16 healthy subjects. NK cell activity was deficient in PNH and pretreatment of mononuclear cells with human leucocyte interferon in vitro failed to normalize this abnormality. The deficient NK cell activity may result from an abnormality of a lymphocyte subpopulation not described previously.