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Regeneration of peripheral blood cells following allogeneic bone marrow transplantation for severe aplastic anaemia
Author(s) -
Hows J. M.,
Kaffaf S.,
Palmer S.,
Harris R.,
Fairhead S.,
GordonSmith E. C.
Publication year - 1982
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1982.tb03930.x
Subject(s) - medicine , regeneration (biology) , peripheral blood , bone marrow transplantation , aplastic anemia , bone marrow , peripheral blood stem cells , transplantation , immunology , pathology , biology , hematopoietic stem cell transplantation , microbiology and biotechnology
S ummary . We have studied the pattern of regeneration of peripheral blood cells following ABO compatible bone marrow transplantation for severe aplastic anaemia. 18 patients were treated with cyclosporin A and six with methotrexate for post graft immunosuppression. The number of days taken for the neutrophil count to reach 0.5 × 10 9 /l, the lymphocyte count to reach 1.0 x 10 9 /l, the platelet count to reach 100 × 10 9 /l and the reticulocytes to reach 1% was shorter in the CyA treated patients. This finding reached statistical significance for all types of cells except the platelets (neutrophils, P < 0.001; lymphocytes, P < 0.02; platelets, P > 0.05; reticulocytes, P < 0.001).