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A comparative study of carrier detection in haemophilia A by linear discriminant function
Author(s) -
Shen MingChing
Publication year - 1982
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1982.tb03891.x
Subject(s) - haemophilia a , linear discriminant analysis , haemophilia , chemistry , medicine , statistics , mathematics , surgery
S ummary . Blood samples collected from 37 definite carriers, 31 normal women and 64 possible carriers were examined for factor VIII‐related activities. Five variables: factor VIII coagulant activity (VIII:C) (X 1 ), factor VIII‐related antigen (VIIIR:Ag) (X 2 ), ristocetin co‐factor (VIIIR:RC) (X 3 ), ratio of VIIIR: Ag to VIII:C (A/C) (X 4 ) and ratio of VIIIR: RC to VIII:C (R/C) (X 5 ), and 28 combinations of one to five variables were used to derive 28 linear discriminant functions. The calculation of discriminant function coefficient, individual discriminant score and cut‐off point, and the identification of normals or carriers were processed by the computer package of a biomedical computer program used at University of California at Los Angeles. A comparison of 28 linear discriminant functions for carrier detection in haemophilia A has indicated that the best and simplest is y=0.11668X 1 (VIII:C)‐0.06042X 2 (VIIIR:Ag), (cut‐off point =2.03742). It identified 94.6% of carriers without a single misclassification in the normal group, and the overall identification rate was 97.1%. Of 29 daughters of definite carriers who had no haemophilic sons, 13, or 44.8%, could be identified as carriers. It was found that VIIIR:RC was not as good as VIIIR:Ag for carrier detection; however, it may be concluded from this study that VIIIR:RC can be used as a supplement, if not a substitute, for VIIIR:Ag in the carrier detection of haemophilia A.