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G Γ and A Γ globin chain synthesis in bone marrow and peripheral blood of β‐thalassaemia homozygotes
Author(s) -
Saglio G.,
Camaschella C.,
Guerrasio A.,
Cambrin G. Rege,
Capaldi A.,
Pich P. G.,
Trento M.,
Mazza U.
Publication year - 1982
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1982.tb03884.x
Subject(s) - bone marrow , peripheral blood , ineffective erythropoiesis , globin , erythropoiesis , peripheral , medicine , microbiology and biotechnology , immunology , pathology , biology , anemia , hemoglobin
S ummary .G γ, A γ and β globin chain synthesis has been investigated in the peripheral blood and bone marrow from eight β‐thalassaemia homozygotes. In five out of eight cases total γ chain synthesis was higher in the peripheral blood than in the bone marrow; in seven out of eight cases A γ chain synthesis was markedly higher in the marrow than in the peripheral blood. These data suggest that ineffective erythropoiesis selects F‐cells synthesizing the largest amounts of G γ chains, while A γ producing cells are preferentially destroyed in the marrow.