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Expression of Receptors for IgA in Hairy‐Cell and Other B‐Cell Leukaemias
Author(s) -
Lydyard Peter M.,
Powell Robert G.,
Fanger Michael W.,
Worman Colin P.,
Cawley John C.
Publication year - 1981
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1981.tb07275.x
Subject(s) - receptor , cell , b cell , immunology , biology , hairy cell leukemia , chronic lymphocytic leukemia , hairy cell , leukemia , cancer research , antibody , genetics
S ummary . In six cases of both hairy‐cell leukaemia (HCL) and chronic lymphocytic leukaemia (CLL) it was shown that the pathological cells express receptors for the Fc portion of IgA (RFcα). Many of the cells simultaneously expressed receptors for IgA, IgM and IgG, and blocking studies showed that these are distinct receptors. In contrast, the malignant cells of most of the various other B‐cell leukaemias studied showed low levels of RFcα expression. The significance of the results is briefly discussed and it is suggested that receptor expression may be a marker of certain stages of B‐cell development.