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THYMIDINE KINASE ISOENZYMES IN CHRONIC LYMPHOCYTIC LEUKAEMIA
Author(s) -
Ellims Peter H.,
Gan T. Eng,
Van der Weyden Martin B.
Publication year - 1981
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1981.tb07251.x
Subject(s) - isozyme , thymidine kinase , chronic lymphocytic leukemia , medicine , peripheral blood , thymidine , disease , immunology , biology , enzyme , leukemia , biochemistry , dna , virus , herpes simplex virus
S ummary . The profile of thymidine kinase isoenzymes was determined in peripheral blood lymphocytes from 14 patients with chronic lymphocytic leukaemia (CLL) and 31 controls. Twelve patients with indolent disease showed TK2 isoenzyme activity, while two patients in whom the disease evolved and two patients who presented with aggressive disease exhibited TK1 isoenzyme activity. The demonstration of TK1 activity in the peripheral blood lymphocytes of clinically aggressive CLL suggests that this isoenzyme may be a useful biochemical marker of such behaviour.