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Diurnal Levels of Immunoreactive Erythropoietin in Normal Subjects and Subjects with Chronic Lung Disease
Author(s) -
Miller Marilyn E.,
Garcia Joseph F.,
Cohen Ruth A.,
Cronkite Eugene P.,
Moccia Giuseppe,
Acevedo Julio
Publication year - 1981
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1981.tb07215.x
Subject(s) - medicine , diurnal temperature variation , circadian rhythm , erythropoietin , endocrinology , lung , atmospheric sciences , geology
S ummary . Serum levels of immunoreactive erythropoietin (Ep) were measured in 48 normal male and female volunteers, ages 20‐60 years, to establish a control value for Ep of 18·5±5·0 (x̄ SD) mU/ml. Levels of the hormone were also measured sequentially over a 24 h period of time in an additional 17‘normal’volunteers with no diurnal variation. Diurnal levels of immunoreactive Ep were also measured in 30 subjects with chronic lung disease. These patients, in contrast to normal subjects, exhibited a diurnal variation in the level of immunoreactive Ep with peak levels occurring at midnight. The only variable measured which correlated with the serum immunoreactive Ep level in subjects with chronic lung disease was the level of carboxyhaemoglobin ( P <0·02).