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Idiopathic Myelofibrosis: a Possible Role for Immune‐Complexes in the Pathogenesis of Bone Marrow Fibrosis
Author(s) -
Cappio F. Caligaris,
Vigliani R.,
Novarino A.,
Camussi† G.,
Campana D.,
Gavosto F.
Publication year - 1981
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1981.tb07192.x
Subject(s) - pathogenesis , myelofibrosis , bone marrow , immune system , immunology , medicine , fibrosis , immune complex , pathology
S ummary . Sixteen patients with idiopathic myelofibrosis (IM) have been investigated with respect to the possibility that immune mechanisms may be of importance in the pathogenesis of bone marrow fibrosis. The following points appear relevant: (1) immune‐complexes (IC) are detectable with different techniques in a high percentage of patients with IM. Their presence is associated with evidence of bone‐marrow histological markers of immune activity. (2) IgG is the main Ig class in the composition of IM IC. The results obtained favour the hypothesis that autoimmune mechanisms are involved in IM patients.