Premium
Effect of Oxymetholone on Human Cyclic Haematopoiesis
Author(s) -
Roozendaal K. J.,
Dicke K. A.,
Boonzajer Flaes M. L.
Publication year - 1981
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1981.tb02778.x
Subject(s) - haematopoiesis , reticulocyte , bone marrow , in vitro , myeloid , platelet , monocyte , progenitor cell , medicine , endocrinology , andrology , biology , microbiology and biotechnology , stem cell , biochemistry , messenger rna , gene
S ummary . A 62‐year‐old woman had recurrent fluctuations of neutrophil, monocyte, reticulocyte and platelet counts with a cycling time of 38.5 d. Periodic fluctuations of granulo‐, erythro‐ and megakaryopoiesis were also demonstrated in her bone‐marrow. Oxymetholone reduced the magnitude of the profound cyclic fluctuations in all these cell lines. During treatment a reduced number of in vitro CFU‐C of the progenitor myeloid series from the bone marrow was observed. Using the patient leucocytes as feeders for normal control marrow cells, indication was found for a fluctuation in colony stimulating activity in vitro , rising above normal at the nadir of the WBC.