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Splenic Irradiation in B‐Prolymphocytic Leukaemia
Author(s) -
Oscier D. G.,
Catovsky D.,
Errington R. D.,
Goolden A. W. G.,
Roberts P. D.,
Galton D. A. G.
Publication year - 1981
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1981.tb02755.x
Subject(s) - prolymphocytic leukemia , spleen , white blood cell , medicine , nuclear medicine , gastroenterology , irradiation , pathology , leukemia , physics , chronic lymphocytic leukemia , nuclear physics
S ummary . Twelve patients with B‐cell prolymphocytic leukaemia (PLL) were treated with splenic irradiation at a weekly dose of 100 cGy to a maximum total dose of 1000 cGy. There was no morbidity associated with this treatment. Seven patients responded. Three achieved a good response and four a partial response. Two of the patients who had a partial response have subsequently died of unrelated causes. Four of the five patients who failed to respond have died as a result of their disease. When more than 25% of the prolymphocytes formed rosettes with mouse red blood cells (MRBC) the patients appeared to respond better to splenic irradiation. There was no correlation between response and the initial white cell count or the size of the spleen.