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Reduced Generation of Procoagulant Activity by Endotoxin‐stimulated Mononuclear Cells from Patients with Chronic Myeloid Leukaemia
Author(s) -
Cortellazzo S.,
Viero P.,
Barbui T.,
Colucci M.,
Semeraro N.
Publication year - 1981
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1981.tb02742.x
Subject(s) - peripheral blood mononuclear cell , medicine , myeloid , stimulation , immunology , chronic myeloid leukaemia , in vitro , myeloid cells , biology , biochemistry
S ummary. The capacity of blood mononuclear cells to produce procoagulant activity upon stimulation with bacterial endotoxin in vitro was studied in 21 untreated patients with chronic myeloid leukaemia (CML). Procoagulant activity developed by patients’ cells after prolonged incubation with endotoxin was significantly lower than that produced by cells from a matched control group ( P < 0·001). Reduced activity was seen in all patients when each of them was compared to a matched control studied simultaneously. It was below 50% of the control in 19 patients, and in eight of these it was less than 10%. These findings suggest that qualitative abnormalities in mononuclear cell function may exist in CML and might explain why these patients are less prone to thrombotic complications than those with other myeloproliferative diseases.