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A Complex Ph 1 Translocation in a Patient with Primary Thrombocythaemia
Author(s) -
Fitzgerald P. H.,
McEwan Christine,
Fraser Jan,
Beard M. E.J.
Publication year - 1981
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1981.tb02686.x
Subject(s) - chromosomal translocation , primary (astronomy) , medicine , chemistry , physics , biochemistry , gene , astronomy
S ummary . Routine blood examination of a 27‐year‐old female revealed a platelet count of 2000 10 9 /1. Bone marrow cells showed the Philadelphia chromosome which was one product of a complex rearrangement of chromosomes 9, 22 and X. Her platelet count was lowered by plateletphoresis and chemotherapy. She remains in good health 19 months later, but her thrombocythaemia is considered to be an early manifestation of chronic myeloid leukaemia.