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Interaction between the Glucose‐6‐Phosphate Dehydrogenase Deficiency and Thalassaemia Genes at Phenotype Level
Author(s) -
Sanna G.,
Frau F.,
Melis M. A.,
Galanello R.,
Virgiliis S. De,
Cao A.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb08709.x
Subject(s) - glucose 6 phosphate dehydrogenase , glucosephosphate dehydrogenase deficiency , medicine , dehydrogenase , beta thalassaemia , thalassemia , enzyme assay , red cell , hemoglobinopathy , phenotype , enzyme , beta thalassemia , hemolytic anemia , endocrinology , biology , gene , immunology , biochemistry
Summary. No significant differences were observed in the mean values of Hb A 2 levels and red cell indices between G6PD ‐ and G6PD+β thalassaemia carriers apart from the MCV, which was significantly higher in β thalassaemia G6PD ‐ subjects, but still in the thalassaemia carrier range. No difference was seen between G6PD+ and G6PD ‐ α thalassaemia carriers. G6PD+β thalassaemia carriers show a significant increase in G6PD levels expressed as activity per g of Hb and to lesser extent as activity per number of red cells x 10 9 ; in G6PD+α thalassaemia carriers this increase is statistically significant only when the enzyme levels are expressed as activity per g of Hb. G6PD ‐ β thalassaemia carriers had enzyme levels higher than non‐thalassaemic G6PD ‐ subjects only when the activity is expressed per g of Hb. G6PD activity was found to be increased in G6PD+ and G6PD ‐ Hb H disease patients.