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Coagulation Factors in the Human Fetus of about 20 Weeks of Gestational Age
Author(s) -
Terwiel Jack Ph.,
Veltkamp Jan J.,
Bertina Rogier M.,
Muller Hein P.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb07187.x
Subject(s) - factor ix , coagulation , antithrombin , haemophilia , fibrinogen , medicine , factor vii , fetus , haemophilia a , prothrombin complex , gestational age , risk factor , endocrinology , gastroenterology , pregnancy , surgery , heparin , biology , genetics
S ummary In plasma samples of 11 fetuses of about 20 weeks of gestational age the following coagulation factors have been determined (mean values found are given in parentheses): fibrinogen (0·30 U/ml), prothrombin (±0·17 U/ml), factor V (0·28 U/ml), factor VII (0·21 U/ml), factor VIII coagulant activity (factor VIII:C) (0·12 U/ml), factor VIII‐related antigen (factor VIIIR:Ag) (1·04 U/ml), coagulant factor VIII‐related antigen (factor VIII:CAg) (0·19 U/ml), factor IX coagulant activity (0·05 U/ml), factor IX antigen (≤0·03 U/ml), factor X (0·19 U/ml) and antithrombin III (AT‐III) (0·23 U/ml). Our data support the evidence that prenatal diagnosis of haemophilia A is at present possible; less optimism is warranted where haemophilia B is concerned. The number of samples is sufficient to establish normal values for the age group. Means of quality control of the sample—which is often difficult to obtain—are discussed.