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In Vitro Effect of Cyclophosphamide Metabolites on Chromosomes of Fanconi Anaemia Patients
Author(s) -
Berger R.,
Bernheim A.,
Gluckman E.,
Gisselbrecht C.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb07179.x
Subject(s) - cyclophosphamide , in vitro , bone marrow , lymphocyte , immunology , chemotherapy , medicine , biology , endocrinology , chemistry , cancer research , pharmacology , genetics
S ummary The effect of cyclophosphamide metabolites was studied on chromosomes of Fanconi anaemia patients, parents and controls. A high susceptibility of FA patients chromosomes was observed when low concentrations of sera of a cyclophosphamide‐treated patient was added to PHA‐stimulated lymphocyte cultures. No effect was observed with comparable concentrations on cells from FA patients or controls. The high susceptibility of FA cells is discussed in relation to the high sensitivity of FA patients to cyclophosphamide when used as a conditioning drug for bone marrow graft.