Premium
Measurement of Erythropoiesis using 52 Fe
Author(s) -
Ferrant A.,
Cauwe F.,
Cogneau M.,
Beckers C.,
Verwilghen R.,
Sokal G.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb07164.x
Subject(s) - erythropoiesis , ineffective erythropoiesis , medicine , anemia , chemistry
S ummary A method for determining erythropoiesis quantitatively with 52 Fe has been applied to 25 patients with anaemia. The data were derived from quantitative scanning of the erythropoietic areas and the measurement of the plasma iron turnover. We have assessed this 52 Fe measurement of erythropoiesis by comparing it with total marrow iron turnover studies. Both methods give similar estimates of erythropoiesis except in patients with severe ineffective erythropoiesis and in a patient with significant peripheral haemolysis, when erythropoiesis as measured with the 52 Fe technique gave higher results. In these conditions, the estimate of total erythropoiesis might be more reliable using the 52 Fe quantitative scanning technique. However, the measurement of erythropoiesis with 52 Fe does not distinguish effective from ineffective erythropoiesis and cannot be applied to patients with extramedullary erythropoiesis.