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An Extrinsic Factor Controls Neutrophil Alkaline Phosphatase Synthesis in Chronic Granulocytic Leukaemia
Author(s) -
Rustin Gordon J. S.,
Goldman John M.,
McCarthy Donald,
Mees Steven,
Peters Timothy J.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb07158.x
Subject(s) - alkaline phosphatase , nap , chronic granulocytic leukemia , neutrophile , immunology , in vivo , phosphatase , chemistry , microbiology and biotechnology , medicine , cancer research , biology , leukemia , biochemistry , enzyme , inflammation , genetics , neuroscience
S ummary The mechanism underlying the reduced neutrophil alkaline phosphatase (NAP) activity in chronic granulocytic leukaemia (CGL) has been investigated by in vivo manipulation of CGL neutrophils. These cells, which had almost no alkaline phosphatase activity following collection by leucapheresis, had greatly elevated activities 14–17 h after transfusion into three neutropenic recipients. It is postulated that NAP synthesis in mature neutrophils is controlled by an extrinsic factor and that the levels of this factor is reduced in patients with CGL with high neutrophil counts.