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Transient Increase of Fetal Haemoglobin in Kala‐azar
Author(s) -
Schilirò G.,
Musumeci S.,
Russo A.,
Marino S.,
Sciotto A.,
Russo G.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb05959.x
Subject(s) - fetal hemoglobin , erythropoiesis , fetus , umbilical cord , andrology , immunology , heinz body , medicine , biology , chemistry , hemoglobin , anemia , pregnancy , genetics
S ummary . Haemoglobin F (HbF) levels were significantly increawd in 40 children with kala‐azar in comparison with controls (3.36 ± 2.32 versus 0.90±1.8; P <0.01). The HbF was heterogeneously distributed among the red blood cells. The glycine residue of peptides γ CN 3 were within the normal umbilical cord blood range, and the haemoglobin synthesis in vitro was balanccd. After recovery from kala‐azar the HbF fell within the normal range. These results suggest that increased production of HbF is associated with accelerated erythropoiesis due to temporary marrow stress.