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Circulating Granulocytic and Erythroid Progenitor Cells in Chronic Granulocytic Leukaemia
Author(s) -
Goldman John M.,
Shiota Fatih,
Th'ng K. H.,
Orchard Kim H.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb05929.x
Subject(s) - progenitor cell , erythropoietin , granulocyte , progenitor , precursor cell , cfu gm , biology , immunology , monocyte , colony forming unit , microbiology and biotechnology , bone marrow , in vitro , stem cell , endocrinology , biochemistry , genetics , bacteria
S ummary . We used a standard methyl cellulose method to assay erythroid progenitor cells in the blood of 35 patients with untreated CGL and of 18 normal controls. In 28 patients we simultaneously assayed granulocyte/nionocyte committed progenitor cells (CFU‐c) by an agar method. Circulating erythroid burst‐forming units (HFU‐e) in CGL wcre increased above normal by a factor of about 180; CFU‐c were increascd by a factor of about 9000. Both BFU‐e and CFU‐c numbers were linearly related to the total leucocyte count in individual patients but not to numbers of circulating blast cells. There was a positive correlation in individual patients between CFU‐c and BFU‐e numbers. Circulating BFU‐e and erythroid colony‐forming cells (CFU‐e) were unable to proliferate in vitro in the absence of erythropoietin. We conclude that erythroid progenitor cells are involved in the‘clonal expansion’that characterizes CGL, but apparently to a lesser extent than are granulocyte/monocyte progenitor cells.