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Red Cell Pyrimidine 5′‐Nucleotidase and Glutathione in Myeloproliferative and Lymphoproliferative Disorders
Author(s) -
Lieberman J. E.,
GordonSmith E. C.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb05912.x
Subject(s) - chronic lymphocytic leukemia , medicine , lymphoma , lymphoproliferative disorders , immunology , multiple myeloma , nucleotidase , 5' nucleotidase , hematology , bone marrow , pathology , leukemia , adenosine
S ummary . Red cell reduced glutatione (GSH) and pyrimidine 5′‐nucleotidase (Pyr 5′‐NT) were measured in a variety of myeloproliferative and lymphoproliferative disorders. Raised levels of GSH were found in chronic lymphocytic leukaemia, Hodgkin's disease, non‐Hodgkin's lymphoma, Waldenstrom's macroglobulinaemia and myeloma. Decreased activity of Pyr 5′‐NT was found in acute myeloblastic leukaemia, acute lymphoblastic leukaemia, chronic granulocytic leukaemia, chronic lymphocytic leukaemia, Hodgkin's disease and non‐Hodgkin's lymphoma. There was no correlation between the raised GSH levels and decreased Pyr 5′‐NT levels.