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Familial Association of the Lupus Anticoagulant
Author(s) -
Exner T.,
Barber S.,
Kronenberg H.,
Rickard K. A.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb03814.x
Subject(s) - lupus anticoagulant , coagulation , coagulation testing , medicine , immunology , genetic predisposition , sibling , systemic lupus erythematosus , anticoagulant , disease , antibody , psychology , developmental psychology
S ummary . A lupus anticoagulant was detected in plasma from two pairs of siblings using the kaolin clotting time mixing test. Strong evidence for this inhibitor in one further sibling pair is presented. Although coagulation abnormalities are usually classified as either acquired or of genetic origin it is apparent that the lupus anticoagulant might often be an acquired coagulation defect requiring genetic predisposition.