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Increase in Coagulation Factor VIII Activity in Man following Acute Hypoglycaemia: Mediation via an Adrenergic Mechanism
Author(s) -
Corrall R. J. M.,
Webber R. G.,
Frier B. M.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb01212.x
Subject(s) - metoprolol , saline , propranolol , medicine , endocrinology , coagulation , mediation , adrenergic receptor , adrenergic , receptor , political science , law
S ummary . Coagulation factor VIII activity has been assayed in nine normal volunteers before and after acute hypoglycaemia. In all subjects there was a rise in activity with a mean increment of 96%. Control studies using saline failed to demonstrate any change. In four subjects with pre‐ganglionic sympathectomy no increase in activity was observed. In the normal subjects the increase was blocked by propranolol but not by metoprolol, indicating mediation via beta 2 receptors.