Premium
Kinetics, Distribution and Sites of Destruction of 111 Indium‐labelled Human Platelets
Author(s) -
Heyns A. duP.,
Lötter M. G.,
Badenhorst P. N.,
Reenen O. R.,
Pieters H.,
Minnaar P. C.,
Retief F. P.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb01209.x
Subject(s) - platelet , spleen , chemistry , nuclear medicine , bone marrow , distribution (mathematics) , pathology , medicine , mathematical analysis , mathematics
S ummary . The survival, tissue distribution and fate of 111 In‐oxine labelled autologous platelets in six normal humans were studied with serial blood sampling, scintillation camera and computer‐assisted imaging, whole body profile scanning, and rectilinear scanning. 111 In‐platelets recovery in the circulation was 72±16% and survival was 216±17 h. Platelet survival curves fitted a linear function best. Initially platelets pooled rapidly in the spleen as a single exponential function, and at 90 min 26% of the injected 111 In was located in this organ. Early hepatic uptake was also significant and at 90 min constituted 16% of total body 111 In‐activity. As labelled platelets disappeared from the circulation there was a threefold increase of radioactivity in the liver to reach 39% of whole body activity at 216 h. Radioactivity also increased significantly in the spleen (33±3% at 216 h). There was significant residual radioactivity in the thoracic and lower abdominal regions at 216 h, suggesting that platelets are also sequestered in the bone marrow. Radioactivity in the lower limbs almost disappeared with time (0±7% at 216 h), indicating that utilization of platelets in the peripheral vasculature is not marked in normal subjects.