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Heparin and Partial Thromboplastin Time: an International Survey
Author(s) -
Poller L.,
Thomson J. M.,
Yee K. F.
Publication year - 1980
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1980.tb01193.x
Subject(s) - partial thromboplastin time , heparin , anticoagulant , medicine , prothrombin time , thromboplastin , platelet , coagulation
S ummary . The reliability of routine partial thromboplastin time (PTT) methods in the measurement of the anticoagulant effect of heparin has been assessed in a study involving over 300 hospitals in the U.K. and overseas. Commercial PTT methods were relatively insensitive to heparin, added in vitro , compared with the standardized PTT method tested by the same laboratories. Non‐commercial, locally‐prepared reagents compared well with the standardized method particularly in the detection of a low concentration of heparin. The value of a sensitive reference preparation for the calibration of routine PTT reagents used in heparin control is demonstrated.