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Comparison of in Vitro Effects of Normal IgG and of a Monoclonal IgG on the Rheological Behaviour of Erythrocytes
Author(s) -
Rovel A.,
Vigneron C.,
Streiff F.
Publication year - 1979
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1979.tb05888.x
Subject(s) - in vitro , monoclonal antibody , rheology , monoclonal , chemistry , immunology , medicine , biochemistry , antibody , physics , thermodynamics
S ummary . Erythrocyte sedimentation, viscosity, electrophroetic mobility, and osmotic fragility were measured in a study of the rheological behaviour of the erythrocyte in vitro . In comparison with physiological saline solution, a suspending medium containing a γ 2 γ 2 monoclonal IgG from a patient with multiple myeloma caused rheological changes 2–3 times as great as a medium with normal IgG. Our results demonstrate the existence of nonimmunological interactions between erythrocytes and normal or monocolonal immunoglobulins, and they raise questions about the widely held assumption that paraproteins are structurally ‘normal’.