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Diagnosis of Haematological Disease using Anti‐i
Author(s) -
Shumak Kenneth H.,
Rachkewich and Rose A.,
Beldotti Lorraine E.
Publication year - 1979
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1979.tb05874.x
Subject(s) - disease , medicine , intensive care medicine
S ummary . Leukaemic blast cells were obtained from the blood of six patients with acute lymphoblastic leukaemia (ALL) and 15 patients with acute myeloblastic leukaemia (AML). The blasts were compared with lymphocytes from normal subjects in cytotoxicity and 125 I‐labelled antibody binding tests using several examples of anti‐i. As much i antigen was detected on ALL blasts as on normal lymphocytes; much less i antigen was detected on AML blasts. Studies of three patients with morphologically undifferentiated acute leukaemia suggest that, in tests with anti‐i, blasts from such patients react either like lymphoblasts or myeloblasts despite the absence of the corresponding morphological features.