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Liposome Entrapped Desferrioxamine and Iron Transporting Ionophores: a New Approach to Iron Chelation Therapy
Author(s) -
Young S. P.,
Baker E.,
Huehns E. R.
Publication year - 1979
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1979.tb05868.x
Subject(s) - liposome , chelation , excretion , pharmacology , chelation therapy , chemistry , deferoxamine , medicine , biochemistry , inorganic chemistry
S ummary . Liposome‐entrapped desferrioxamine was administered to iron‐overloaded 59 Fe labelled mice. When given orally or intraperitoneally entrapment did not enhance the effect of the chelator, but given intravenously liposomal desferrioxamine doubled the 59 Fe excretion for a given dose of the drug, and excretion after a single dose continued for up to 3 d. In addition, liposomes containing ionophore A23187 administered concurrently with DTPA caused an excretion of 59 Fe, whereas DTPA alone had no effect.