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New Translocations in Chronic Granulocytic Leukaemia: t(X;22) (p22;q11) and t(15;22) (q26;q11)
Author(s) -
Hossfeld D. K.,
Köhler S.
Publication year - 1979
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1979.tb05847.x
Subject(s) - basophilia , chromosomal translocation , thrombocytosis , bone marrow , trisomy , chromosome , biology , karyotype , pathology , medicine , cancer research , microbiology and biotechnology , immunology , genetics , platelet , gene
S ummary . Two cases of Ph 1 ‐positive chronic granulocytic leukaemia with hitherto undescribed translocations are presented. In case 1 the deleted part of chromosome number 22q‐ was translocated to the short arm of the X chromosome, t(X;22)(p22;q11). Pronounced basophilia, trisomy 19 in the majority of metaphases, and a partial cytogenetic normalization of the bone marrow during busulphan induced remission were additional remarkable features of this case. In case 2 a translocation t(15;22)(q26;q11) was found. In this case the disease was characterized by an increase of unusually small megakaryocytes, thrombocytosis, and an accelerated course.