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Granulecyte‐specific Alloantigen Loss in Chronic Granulocytic Leukaemia
Author(s) -
Reijden H. J. v. d.,
Von Dem Borne A. E. G. Kr.,
Verheugt F. W. A.,
Floorvan Gent A. B.,
Melief C. J. M.,
Engelfriet C. P.
Publication year - 1979
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1979.tb03791.x
Subject(s) - medicine , immunology , chronic myeloid leukaemia
Summary. The granulocytes of 23 patients with chronic granulocytic leukaemia were examined in the indirect immunofluorescence test and some also in the microleucoagglutination test, with specific alloantisera against the NA 1 , NA 2 , NB 1 , and ND 1 antigens and a specific granulocyte xenoantiserum. In 10 cases a complete loss of alloantigens was detected. In one patient a partial loss was found. A significant correlation was established between this loss and an accelerated activity (impending blast crisis) of the disease.