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Cell Surface Heterogeneity of Human Blood Neutrophils and Monocytes
Author(s) -
Barrett Sondra,
Garratty Eileen,
Garratty George
Publication year - 1979
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1979.tb03790.x
Subject(s) - myeloid , receptor , immunology , fc receptor , myeloid cells , cell , monocyte , biology , complement receptor , cell surface receptor , antibody , microbiology and biotechnology , chemistry , complement system , biochemistry
Summary. Until recently, human blood neutrophils (PMN) and monocytes have been considered to be homogeneous cell populations. However, much evidence has accumulated on their functional heterogeneity. This functional heterogeneity suggests the existence of different subsets of myeloid cells analogous to T and B subsets of lymphoid cells. The goal of this study was to investigate this question of myeloid subsets by examining myeloid cells for cell surface reactivity for IgG and complement (C). Normal PMN and monocytes were examined from 60 subjects for the presence of two types of IgG‐Fc receptors and two activated C components, C 3 b and C 3 d. Most PMN and monocytes showed Fc receptor reactivity for rabbit IgG (Fc‐R). In addition, the majority of monocytes but very few PMN reacted with human IgG (anti‐Rh 0 ) coated Rh‐positive erythrocytes (Fc‐H). Most PMN and monocytes showed C receptor reactivity for C 3 b, but only a minor subpopulation of both myeloid cells had C 3 d receptors. These data provide evidence that human blood myeloid cells may be composed of subsets with different membrane marker reactivities.