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Splenic Irradiation in Myelofibrosis: Effect on Circulating Myeloid Progenitor Cells
Author(s) -
Koeffler H. Phillip,
Cline Martin J.,
Golde David W.
Publication year - 1979
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1979.tb03721.x
Subject(s) - myelofibrosis , granulopoiesis , myeloid , progenitor cell , spleen , pathology , medicine , myelopoiesis , granulocyte , flow cytometry , immunology , cancer research , bone marrow , biology , stem cell , microbiology and biotechnology
S ummary . We have investigated the mechanism of splenic irradiation‐induced granulocytopenia in two patients with myelofibrosis and marked splenomegaly. Serial assays were performed for circulating granulocyte‐monocyte progenitors capable of colony formation in vitro (CFU‐C). For comparison, similar studies were performed on two patients receiving whole brain irradiation for glioma. Splenic irradiation caused a significant decrease in circulating CFU‐C in the myelofibrosis patients. There was no decrease in circulating CFU‐C in the brain‐irradiated patients. No radiation‐induced humoral inhibitor of granulopoiesis and no increased CFU‐C radiosensitivity could be demonstrated in the myelofibrosis patients. These observations, taken together with previous data on splenic blood flow and pooling, suggest that the major mechanism of irradiation‐induced granulocytopenia in myelofibrosis is destruction of proliferating precursor cells in the splenic tissue and sinusoids.