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Defective Hydrogen Peroxide Production in Chronic Granulocytic Leukaemia Neutrophils
Author(s) -
ElMaallem Hilal,
Fletcher John
Publication year - 1979
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1979.tb03680.x
Subject(s) - phagocytosis , hydrogen peroxide , incubation , neutrophile , granulocyte , chronic granulomatous disease , immunology , incubation period , chemistry , microbiology and biotechnology , biology , medicine , biochemistry , inflammation
S ummary . Hydrogen peroxide (H 2 O 2 ) production by polymorphonuclear neutrophils (PMN) during phagocytosis was fluorometrically estimated over an incubation period of 80 min during which dead Candida guilliermondii were ingested. Ten patients with chronic granulocytic leukaemia (CGL) were tested and compared with 15 normal subjects. The production of H 2 O 2 by CGL neutrophils was about 29% of normal. There was no correlation between H 2 O 2 production and the impaired killing of Candida guilliermondii by the neutrophils of CGL patients.