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Ultrastructural Analysis of Haemopoiesis in W/W v Anaemic Mice
Author(s) -
Shaklai Matityahu,
Tavassoli Mehdi
Publication year - 1978
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1978.tb05809.x
Subject(s) - haematopoiesis , ultrastructure , heterochromatin , stem cell , biology , microbiology and biotechnology , andrology , immunology , dna , genetics , medicine , anatomy , chromatin
S ummary . This study is an ultrastructural analysis of haemopoiesis in W/W v anaemic mice in whom the anaemia is caused by a defect in the haemopoietic stem cell. Cellularity of marrow is normal but there is an increase in the proportion of less mature cells suggesting a delay in maturation. In addition, heterochromatin constitutes a higher proportion than normal of the nucleus in most stages of maturation suggesting a defect in DNA activation. The findings suggest that in this strain not only the differentiation of the haemopoietic stem cell but also the maturation of the committed cell is defective.