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Cell Membrane Enzymes II.
Author(s) -
Kramers Mary T. C.,
Catovsky D.,
Foa R.
Publication year - 1978
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1978.tb03644.x
Subject(s) - alkaline phosphatase , null cell , enzyme , cord blood , cell , precursor cell , phosphodiesterase , biology , lymphoproliferative disorders , endocrinology , immunology , chemistry , medicine , microbiology and biotechnology , biochemistry , lymphoma , gene
SUMMARY The distribution of two cell membrane enzymes, alkaline phosphatase and alkaline phosphodiesterase I has been studied in normal and leukaemic lymphocytes. No reduction in the level of activity of either enzyme was found in the chronic or acute B‐ and T‐cell leukaemias. Alkaline phosphatase activity was elevated in the lymphocytes from T‐CLL, cord blood and tonsils and the blast cells from Null‐ALL. Alkaline phosphodiesterase was elevated in lymphocytes from cord blood and tonsils and the blast cells from Null‐ALL. As findings in Null‐ALL were based on only two cases, they need confirmation in a larger series. The significance of these results is discussed in relation to current theories of maturation and differentiation in the lymphoproliferative disorders.