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The Surface Morphology of Mitogen‐Stimulated Human Peripheral Blood Lymphocytes
Author(s) -
Newell D. G.,
Roath S.
Publication year - 1978
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1978.tb03632.x
Subject(s) - peripheral blood , mitogen activated protein kinase , morphology (biology) , peripheral , medicine , immunology , microbiology and biotechnology , biology , signal transduction , genetics
The changes occurring in surface morphology during the transformation of normal peripheral blood lymphocytes by phytohaemagglutinin (PHA) are described and the surface ultrastructure of the PHA‐induced blasts is compared with that of pokeweed mitogen (PWM)‐ and rabbit anti‐β 2 ‐microglobulin antiserum‐induced blasts. Both mitogen‐specific and non‐specific changes were observed and their possible relationship to the activation of lymphocyte subpopulations is discussed. Similar surface characteristics found in various tissue lymphoid cells are also described.