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Defective Binding of Thrombin to Platelets in Myeloid Leukaemia
Author(s) -
Ganguly P.,
Sutherland S. B.,
Bradford H. R.
Publication year - 1978
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1978.tb03630.x
Subject(s) - thrombin , platelet , fibrinogen , receptor , stimulation , chemistry , thrombin receptor , thrombin time , cell surface receptor , chronic myeloid leukaemia , myeloid cells , medicine , endocrinology , immunology , biochemistry , partial thromboplastin time
Platelets from patients with myeloid leukaemia showed reduced aggregation with collagen or thrombin. These platelets also had a lower capacity to bind thrombin. This lower thrombin binding is due to a decrease in the total quantity of receptors available and not because of a change in the affinity. In the presence of the patients’plasma, the aggregation behaviour of normal platelets induced by thrombin as well as the clotting time of fibrinogen remained unchanged. The results suggest that the platelet dysfunction in myeloid leukaemia is partially due to a membrane defect involving the thrombin receptors which leads to an impaired induction of the initial stimulation.