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An Immunoradiometric Assay for Factor III (Tissue Thromboplastin)
Author(s) -
Bjørklid Eirik,
Giercksky Karl E.,
Prydz Hans
Publication year - 1978
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1978.tb01115.x
Subject(s) - immunoradiometric assay , tissue factor , thromboplastin , partial thromboplastin time , chemistry , antibody , radioimmunoassay , medicine , microbiology and biotechnology , immunology , coagulation , biology
A solid‐phase immunoradiometric assay for tissue thromboplastin (factor III) has been established based on its displacing effect on the binding of 125 I‐labelled factor III‐antibodies to polyvinyl tubes coated with the purified protein component of factor III (apoprotein III). By this method circulating tissue thromboplastin can be detected in experimental animals receiving infusions of crude or purified tissue thromboplastin and in patients undergoing major orthopaedic surgery.