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The Development of Haemoglobin A 2 in Normal Negro Infants and in Sickle Cell Disease
Author(s) -
Serjeant B. E.,
Mason K. P.,
Serjeant G. R.
Publication year - 1978
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1978.tb01096.x
Subject(s) - disease , fetal hemoglobin , hemoglobinopathy , beta thalassaemia , medicine , pediatrics , hemoglobin a2 , sickle cell anemia , beta (programming language) , genotype , hemoglobin , thalassemia , biology , genetics , pregnancy , gene , fetus , computer science , programming language
The development of haemoglobin A 2 levels from birth to 3 years has been compared in normal, β‐thalassaemia trait, sickle cell (SS) disease, and S‐β‐thalassaemia genotypes. Hb A 2 levels were almost identical in normals and in children with SS disease at 1, 2 and 3 years. The most rapid increases in Hb A 2 levels occurred before 6 months but levels were still rising at the end of the third year. Sickle cell‐β + thalassaemia could be differentiated from SS disease by the higher Hb A 2 levels between 6 months and 1 year. Insufficient data were available on S‐β° thalassaemia but since Hb A 2 levels in this condition are generally higher than those in S‐β + thalassaemia, differentiation from SS disease may also be possible from the age of 6 months.