Premium
Chronic Lymphatic Leukaemia: Cellular Effects of Glucocorticoids in Vitro
Author(s) -
Homo Françoise,
Duval Dominique,
Meyer Philippe,
Belas Fatiha,
Debre Patrice,
Binet JacquesLouis
Publication year - 1978
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1978.tb01074.x
Subject(s) - glucocorticoid receptor , glucocorticoid , in vitro , dexamethasone , uridine , nucleic acid , medicine , lymphatic system , receptor , endocrinology , stage (stratigraphy) , steroid , biology , chemistry , immunology , biochemistry , rna , hormone , paleontology , gene
Glucocorticoid receptor levels and steroid induced inhibition of nucleic acid precursors have been examined in lymphocytes from 27 patients at different stages of chronic lymphatic leukaemia. No correlation can be found between the level of glucocorticoid receptors and the stage of the disease. On the other hand, a significant difference ( P < 0.02) was found between stage 0 and stage III/IV patients, in terms of the in vitro effect of dexamethasone on [ 3 H]uridine incorporation.