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Intracellular λ Light Chain Inclusions in Chronic Lymphocytic Leukaemia
Author(s) -
McCann S. R.,
Whelan A.,
Greally J.
Publication year - 1978
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1978.tb01056.x
Subject(s) - immunoglobulin light chain , intracellular , chronic lymphocytic leukemia , bone marrow , antibody , chemistry , pathology , medicine , immunology , leukemia , biochemistry
A case of chronic lymphocytic leukaemia (CLL) with intracytoplasmic crystalline inclusions in peripheral blood lymphocytes is presented. The inclusions were identified as crystals of lambda (Δ) light chain and were present in bone marrow derived (B‐cells) lymphocytes. The occurrence of light chain crystals in CLL may reflect a more primitive defect in immunoglobulin (Ig) synthesis, intracellular transport or secretion than has previously been reported.