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The Identification of the Products of Folate Catabolism in the Rat
Author(s) -
Murphy Mary,
Boyle Peter H.,
Weir Donald G.,
Scott John M.
Publication year - 1978
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1978.tb01037.x
Subject(s) - catabolism , folic acid , urine , biochemistry , chemistry , vitamin , excretion , cleavage (geology) , metabolism , medicine , biology , paleontology , fracture (geology)
Further analysis of rat urine containing labelled catabolites derived from administered 3 H‐ or 14 C‐labelled folic acid is described. The results support previously described studies, and show that folate catabolism in the rat takes place by cleavage of the C9‐N10 bond, and not by excretion of inactive forms of the vitamin which still contain the intact folate skeleton.