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Monosomy 7 in Two Patients with a Myeloproliferative Disorder
Author(s) -
Boetius G.,
Hustinx T. W. J.,
Smits A. P. T.,
Scheres M.J. C.,
Rutten F.J.,
Haanen C.
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb08815.x
Subject(s) - pancytopenia , monosomy , medicine , bone marrow , pathology , myeloid , preleukemia , myeloproliferative disorders , gastroenterology , pediatrics , karyotype , chromosome , biology , genetics , gene
Summary. Clinical and laboratory data are presented for two patients with a dyshaematopoietic disorder, and monosomy 7 in their bone marrow cells. The first patient, a 55–year‐old woman, had been treated with chlorambucil for an ovarian carcinoma. After 4 years an oligoblastic myeloid leukaemia was diagnosed and she later died with an acute transformation of the disease. The second patient, a 21–year‐old male, has had a dyserythropoietic anaemia with transient pancytopenia for over 5 years without any signs of malignancy. The possible relationship between therapy, the monosomy 7 and the other bone marrow abnormalities is briefly discussed. From an analysis of the data of these and comparable cases in the literature it appears that loss of chromosome No. 7 material is often associated with erythropoietic disorders such as erythroid hyperplasia and erythraemia. The reduction or absence of the Colton blood group antigens found in our patients and in a few other monosomy 7 cases also points to an abnormality of the red cell line.