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Myelotoxicity of Methotrexate in Animals with Pyogenic Infection
Author(s) -
Harding B.,
Lennan I. C. M.
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb01024.x
Subject(s) - neutropenia , methotrexate , medicine , gastroenterology , chemotherapy
S ummary . Rats stimulated into prolonged increased neutrophil production by the induction of a unilateral pyo‐hydronephrosis showed consistent profound neutropenia when methotrexate (MTX) was given during the first 2 d of infection. Thereafter greater neutropenia than that observed in non‐infected rats was only observed in occasional animals. There was a significant correlation between the degree of neutropenia induced by MTX and the day after MTX upon which this occurred. The main target for myelotoxicity by MTX appears to be the myelocyte. Its precursors seem relatively insensitive.