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Radioimmunoassay of Human Eosinophil Cationic Protein
Author(s) -
Venge Per,
Roxin LarsErik,
Olsson Inge
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb01003.x
Subject(s) - eosinophil cationic protein , eosinophil , radioimmunoassay , microgram , granulocyte , eosinophil granule proteins , cationic polymerization , major basic protein , immunology , chemistry , in vivo , medicine , in vitro , biology , biochemistry , microbiology and biotechnology , organic chemistry , asthma
S ummary . A radioimmunosorbent assay has been developed which allows the detection in serum of a cationic protein derived from eosinophil granulocytes. In 34 healthy individuals the mean level was 31 μg/l. with a range of 5–55 μg/l. The serum concentration of ‘eosinophil’ cationic protein was correlated ( P <0.001) to the number of eosinophil granulocytes in peripheral blood. Quantitation of ‘eosinophil’ cationic protein in serum might be useful in the study of eosinophil granulocyte turnover and function in vivo .