Premium
The Effect of Anticonvulsant Drugs on Thymidine and Deoxyribosenucleic Acid Synthesis by Human Marrow Cells
Author(s) -
Taguchi H.,
Laundy M.,
Reid C.,
Reynolds E. H.,
Chanarin I.
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb00638.x
Subject(s) - thymidine , anticonvulsant , in vivo , dna synthesis , microgram , anticonvulsant drugs , deoxyuridine , pharmacology , chemistry , cofactor , dna , in vitro , biochemistry , biology , epilepsy , genetics , enzyme , neuroscience
An abnormal deoxyuridine suppression test was found in treated epileptic patients that did not correlate with other evidence of abnormal folate metabolism. Diphenylhydantoin at a level of 100 μg/ml interfered with the incorporation of [ 3 H]thymidine into DNA. It is suggested that anticonvulsants may exert their effect at a stage of DNA synthesis beyond that at which folate coenzymes operate. Folate deficiency may then arise as a result of death of cells in vivo causing an increased folate requirement.