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Granulocytic Progenitor Cells in Aplastic Anaemia
Author(s) -
Kern P.,
Heimpel H.,
Heit W.,
Kubanek B.
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb00625.x
Subject(s) - bone marrow , progenitor cell , aplastic anemia , peripheral blood , medicine , immunology , bone marrow failure , incidence (geometry) , stimulation , haematopoiesis , peripheral , stem cell , biology , microbiology and biotechnology , physics , optics
The characteristics and the concentration of granulopoietic colony forming cells (CFC) were examined in 22 patients with aplastic anaemia at different stages of their disease. Additionally the ability of the patients’peripheral leucocytes to elaborate factors necessary for colony stimulation in vitro (CSA) was studied. The ability of the patients’cells to generate CSA was shown to be unaffected. However, the incidence of CFC within the marrow and peripheral blood suspensions was significantly reduced in all patients. The results suggest a reduced compartment size of CFC even in those patients who have recovered from aplastic anaemia. This may indicate that the disturbances in the preceding compartments of the haemopoietic cell renewal system still persist after recovery from the acute bone marrow failure.